Bioidentical Hormone Dosing

Is Biomimetic Measurement a Solution to Hormone Replacement Therapy

By T.S. Wiley

Bio-identical hormones can only be genuinely bio-identical if the hormones for replacement mimic not only those chemically found in the body, but also mimic the natural biological process as well.

New study shines brilliant light on healthy hormone replacement therapy
(HRT), suggesting that women should cycle their hormones and experience a menstrual bleed to be really safe from cardiovascular events. According to a recent Danish research, a mixed cyclic regimen with monthly bleeding produces a lower cardiovascular hazard for women than continuous-combined estrogen/progesterone/progestin therapy, which does not produce a menstrual bleed.

The research also proved that current users of HRT showed less risk of having heart attacks than those women who have never taken hormones.

This research is important validation of the value of cyclical (estrogen, followed by a combination of estrogen and progesterone) hormone therapy and that biomimetic hormone restoration therapy (BHRT) may really be healthier than statistically dosed continuous-combined alternatives, whether bio-identical or synthetic.



The primary researcher of this subject, *Dr Ellen L_kkegaard, a gynecologist at the Rigshospitalet in Copenhagen, Denmark, said "The main message is that when hormone therapy is indicated for a woman, then a cyclic combined regimen should be favored, and that application through the skin or the vagina is associated with a decreased risk of myocardial infarction."

The observational research, the broadest to look at the effects of HRT since the Women's Health Initiative (WHI) trial in 1991, followed 698,098 healthy Danish women, aged 51-69.

More women are going back to Hormone Replacement Therapy (HRT) each day, nevertheless, there are a plethora of products on the market that make the right option difficult. As a result women are looking to their doctors for help.

Hesitations about HRT instigated when the National Institute of Health (NIH) patronized WHI's study carried out on over 161,000 women, that was likely to know the advantages and cons of the use hormone restoration therapy in putting a stop to constant illness like heart disease, breast cancer and osteoporosis in postmenopausal women.

The research was stopped halfway through 2002 when WHI researchers proved that the danger of the process of employing artificial therapy have gone beyond the safety limits established at the start of the inquiry.

The result of WHI study treated only women over 65 who were on artificial hormone replacement therapy which comprised of drugs such as PremPro and Premarin only.

The WHI proved that dosing synthetic HRT in a set, low-dose regimen was damaging to woman over 65, particularly in regard to stroke and cardiac effects. After 14 years and almost $800 million taxpayer dollars, the overly emphasized negative results of the WHI were disclosed in May 2002.

The media twist caused millions of women to immediately stop taking their Premarin or Prempro, or any other product taken for a hormone by their doctors, thus leaving millions of symptomatic women without any true clinical guidance.

The WHI in no way examined the hormones but just the medicines with "hormone-like" results that were put in little amounts in regimens extremely that of personal substitute. The study made us see that conjugated equine estrogens (from pregnant mare urine) and artificial progestin (Prempro) when put in small amounts everyday in specified quantity proved hazardous to females with a conflicting information from the same research body a few years back stating that Prempo exhibited helpful results too. The other drug studied, daily Premarin, appeared to show substantially less harmful outcomes. Compounded bio-identical hormones in set doses were not involved in the study because they are prescribed and dosed too many different ways.

Now, in the aftermath of the WHI, acquiring hormones is hard. Physicians are doubtful of the "Standard Of Care" approved artificial drugs. Finding established insurance-covered mainstream physicians to prescribe even bio-identical hormones is a difficulty.

History of HRT
Life expectancy of women in developed nations since 1900 have increased from ages 47 to well over age 80. For the last 150 years it has been evident that the beginning of menopause starts at the age of 50 years old. That means most women are living at least thirty years more than they did at the turn of the century, and about a third of their lives after menopause. Almost 80 percent of women experience diverse fast unbearable symptoms in menopause and 30 percent of those are categorized as severe.

Ten years prior to getting hot flashes and migraine women are liable to feel negative and erratic changes in their monthly periods. Insomnia, fatigue and nervousness add to the advance of aging. Falling of sex hormones and sensitivity of joints also lead to habitual anguish.

Symptoms of menopause can begin as early as the late thirties - yet they are the same miserable disabilities that the elderly face. When hormones plummet, the aging process starts to speed up. Aging usually brings pathology in many forms such as cancer, diabetes, heart disease, glaucoma, depression, and Alzheimer's. If hormone fall-off tells the body that it is growing older, then is it possible that menopause is a trigger for the same illnesses attributed to aging?

Doctors are challenged to come up with a feasible answer to many menopausal problems for Baby Boomers. Almost none, however, have the accurate information on how to prescribe hormones.

Unfortunately, a want of understanding has led numerous doctors to prescribe synthetic drugs with hormone-like results. WHI studies have shown that aside from the harmful effects of artificial drugs, the hormones given in fixed quantity also is not usual for the body. Will aggressive diseases associated with aging be relieved by precisely replacing youthful hormone levels that are gone?

Natural Hormone Replacement Therapy - What is it?
Women are getting a better understanding that not living with hormones is required and that it is dejected and harmful.

What happens when hormone replacement therapy can really copy youthful hormones and not just cover some signs? After all, reasoning would say that young women aren't susceptible to glaucoma, cancer and heart disease, to list a few. The sole importance among young and older women is the reproductive power and their existing hormones. Medicine can testify that many women with average hormones are not likely to get such illnesses.

Natural hormone replacement is known to not leady to any kind of cancer. If estrogen and progesterone, or even testosterone, caused cancer, all young women would be dead. If logic like that informs us that estrogen doesn't really cause cancer in and of itself, then there should be more to the story-like what form of estrogen, how much and when to take it.

A lot of us consider that if a hormone is natural or prepared in a lab then its elements are the same to that of the hormones in the body. End of story. What if it's not the last say? What if it is necessary for the system to identify the foreign stuff like hormones? The same hormone molecules that are substantially developed in a laboratory triggers the action of hormone receptors within the system and can be identified as "natural" but vary in sunstance from naturally occurring hormones but in feasible synergistic system.

Bio-identical Hormone Replacement Therapy (BHRT)
The term bio-identical has basically become a catch-all phrase for anything that is not a synthetic hormone. Scientifically, the term bio-identical means that look-alike molecules synthesized from plants are replaced for our own endogenously-produced hormone molecules. Bio-identical hormone supplies are made from everyday supply of plant hormones that resembles that of the chemical makeup of human hormones. The premise is that the body can't tell created bio-identical hormones from the ones the female ovaries develop naturally.

Numerous bio-identical HRT products are developed at compounding pharmacies from plant derived raw materials such as wild yams or soybeans that have an ability to mimic the molecules found in nature.

Biomimetic: The "How" of Replacing Hormones
Molecules are not the only essential factors. The manner of the receptor site in which the hormones are obtained and are forced may pose an important function in HRT efficiency.

The Wiley Protocol, for instance, is established on the assumption that hormones can be properly "bio-identical" only if they are biomimetic - this entails that they should mimic those found in the body as well as mimic the natural biological process. A woman's body does not produce hormones statically (the same amount each day) but in a rolling and changing rhythm throughout a 28 day cycle. It follows that natural plant derived hormones can correctly be termed bio-identical only when they are given in a biomimetic fashion.

What is absent from various bio-identical and artificial hormone replacement therapies is the common wave-like rhythm of the hormone blood levels in a regular menstrual period of a young woman.

A woman's body makes a rhythm and so does her menstrual cycles. Bio-identical and other artificial hormone replacement therapies have not taken into full consideration the biological clock that determines the usual tempo taking place every day. The typical pace practices one full spin of the planet. The moon remembers the cycle and so does the rhythm of the body.

What does rhythm mean? The body has rhythms that are governed by a primary clock that functions much like a conductor, striking up one part of the body's orchestra as another quiets down, and taking its main cue from light signals in the environment to stay in sync with the 24-hour day. Our hormones rush and wane to this maestro's baton, controlling all endocrine function, particularly a woman's health for reproduction.

Bio-identical hormones can precisely be called bio-identical when the hormones being replaced do not just imitate those inside the body but also the normal biological procedure. This approach may open the door for a different perception at the possible decline or loss of the symptoms and disease conditions linked with menopause and aging.

The Wiley Protocol utilizes these natural rhythms in nature to show the proper doses of estradiol and natural progesterone that simulate the natural hormones which would be produced by a younger body.

A Clinical Study
Women require hormone restoration that is proven to be healthy and reliable. A new study, Bio-identical Hormones On Trial, or B.H.O.T., will soon get at the College of Nursing and Health Sciences at the University of Texas, Tyler. The principal target of the research will be to analyze clinical outcomes and quality of life indicators of patients getting BHRT at 10 to 12 primary care provider's practices. The study will be the catalyst to track and recognize results supported by the giving of or the distribution of BHRT.

Healthcare Prices and Biomimetic Hormone Restoration
With the utilization of authentic biomimetic hormone restoration therapy, women may come across assistance from menopausal symptoms and hence live a more comfortable and healthy life. Medicare and other insurance refunds for constant doctor consults and continuous prescriptions and operations would be reduced. Quality of life would be better for most symptomatic women and many more women would never need to go through the debilitating effects of being without their hormones.

Today, dependable doctors are viewing the more efficient biomimetic hormone restoration. By the year 2030 approximately 57.8 million baby boomers ages 66 and 84 will be living with this health conditions. Those who opt to employ the Wiley Protocol, could live to get an improved life. Consider the possibility.

About the Author
T.S. Wiley is a medical theorist in Darwinian medicine and environmental endocrinology. She is a renowned author, researcher and professor on the consequence of hormones principally in women going through menopause. As a known expert in chronobiology and circadian rhythmicity, in endocrinology, Wiley's CME accredited seminars, "Two Days Back on Earth," are attended by physicians from all over the globe. She is also the main developer of the Wiley Protocol, a brand name patent awaiting the release system of both bio-identical estradiol and progesterone in topical cream preparations administered in a tempo to imitate the typical cycle of hormone levels simulated in serum blood produced by a twenty year old woman.

Wiley is the author with Dr. Julie Taguchi of "Sex, Lies & Menopause," Harper Collins, 2005 and "Lights Out: Sleep, Sugar and Survival," Simon & Schuster, Inc., 2000. Visit www.thewileyprotocol.com, or for more information about the Wiley Protocol Physicians Training and Certification, contact Caren Abdela at 805.565.7508, or email caren@thewileyprotocol.com.



*Ellen L_kkegaard, Anne Helms Andreasen, Rikke Kart Jacobsen, Lars Hougaard Nielsen, Carsten Agger, and _jvind Lidegaard. Hormone therapy and risk of myocardial infarction: a national register study. European Heart Journal, 2008; DOI: 10.1093/eurheartj/ehn408